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Factors Influencing Drug Absorption: Pharmaceutical Parameters

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...

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The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...

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Related Experiment Video

Updated: May 8, 2025

Formation of Dispersible Taohong Siwu Tablets

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

Formulation, Development, and Optimization of Fast Dissolving Tablets Containing Tapentadol Hydrochloride.

Chandrashekar Thalluri¹, Mallikarjun Vasam², Rajkumar Jampala³

¹Department of Pharmaceutics, Faculty of Pharmaceutical Science, Assam Downtown University, Gandhinagar, Panikhaiti, Guwahati-781026, Assam, India.

Pharmaceutical Nanotechnology

|December 24, 2024

Summary

This study developed optimized Tapentadol fast-dissolving tablets (FDTs) using super disintegrants, achieving rapid disintegration and enhanced drug release for better patient compliance. The best formulation followed Fickian diffusion for drug release.

Keywords:

Tapentadol expert design.fast dissolving tablets in-vitro dissolution super disintegrating agents

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Formulation and Characterization of Bioactive Agent Containing Nanodisks

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

Area of Science:

Pharmaceutical Sciences
Drug Delivery Systems

Background:

Tapentadol hydrochloride is a key analgesic for moderate to severe pain.
Fast-dissolving tablets (FDTs) improve patient compliance through rapid pain relief.
Optimizing FDTs requires careful selection of super disintegrants and formulation parameters.

Purpose of the Study:

To fabricate and optimize Tapentadol hydrochloride fast-dissolving tablets (FDTs).
To evaluate the impact of super disintegrants (croscarmellose sodium and crospovidone) on FDT properties.
To determine the optimal formulation using Response Surface Methodology (RSM).

Main Methods:

Formulation of nine Tapentadol hydrochloride FDTs (TH1-TH9) using direct compression.
Optimization of super disintegrant concentrations (croscarmellose sodium, crospovidone) via RSM.
Evaluation of disintegration time, drug release (Q15, Q30), and drug release kinetics using DD Solver.

Main Results:

The TH5 formulation demonstrated the fastest disintegration and highest drug release.
Super disintegrants significantly enhanced Tapentadol hydrochloride solubility and dissolution rate.
Drug release from the optimized TH5 formulation followed first-order kinetics and Fickian diffusion.

Conclusions:

Super disintegrants are critical for optimizing FDT disintegration time and dissolution profiles.
The optimized TH5 formulation offers rapid disintegration and drug release, enhancing patient compliance.
RSM is an effective tool for optimizing FDT formulations with confirmed stability.