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Case Report: A case of infantile acute hyperleukocytic leukemia treated by leukapheresis

Shuang Bian1, Nannan Li1, Hui Gao1

  • 1Department of Hematology and Oncology, Dalian Women and Children's Medical Group, Dalian, China.

Frontiers in Pediatrics
|December 24, 2024
PubMed

Leukapheresis is a treatment used to reduce leukocytes to decrease the number of white blood cells in circulation and prevent the risks of hyperviscosity and cerebrovascular and pulmonary leukostasis. We present a case of pro-B-cell acute lymphoblastic leukemia (ALL) with hyperleukocytosis in a 6-month-old infant, characterized by a positive KMT2A/AFF1 fusion gene with a leukocyte count of 1,755 × 109/L. After two consecutive sessions of leukapheresis, the white blood cell count decreased to 55 × 109/L. The infant recovered after the high-dose methotrexate chemotherapy. These results demonstrate that leukapheresis is a feasible treatment option for acute hyperleukocytic leukemia in infants with ALL.

Keywords:
acute hyperleukocytic leukemiaacute lymphoblastic leukemiainfantleukapheresiswhite blood cells

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