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Updated: May 8, 2025

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke
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Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Published on: July 14, 2023

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Irritability in stroke: a protocol for a prospective study.

Wai Kwong Tang1, Edward Hui1,2, Thomas Wai Hong Leung3

  • 1Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.

Frontiers in Neurology
|December 24, 2024
PubMed
Summary
This summary is machine-generated.

Poststroke irritability (PSI) affects many stroke survivors, impacting quality of life. This study investigates brain imaging (MRI) and clinical factors linked to PSI, examining its 15-month progression.

Keywords:
MRIamygdalaanterior cingulate cortexanterior temporal lobeinsulairritabilityprefrontal cortexstroke

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Area of Science:

  • Neuroscience
  • Neurology
  • Psychiatry

Background:

  • Poststroke irritability (PSI) is a frequent complication following stroke.
  • PSI negatively impacts survivors' quality of life, social interactions, and caregiver well-being.

Purpose of the Study:

  • To evaluate the clinical, neuropsychological, and MRI correlates of PSI.
  • To examine the 15-month progression of PSI in stroke survivors.

Main Methods:

  • Prospective cohort study of 285 stroke survivors and their caregivers.
  • Assessments at 3, 9, and 15 months post-stroke, including the Neuropsychiatric Inventory (CNPI).
  • MRI scans (diffusion-weighted imaging) within 1 week of stroke; logistic regression and ANCOVA for data analysis.

Main Results:

  • This section is not available in the provided abstract.

Conclusions:

  • This study is the first MRI investigation into PSI.
  • Findings will elucidate the association between specific brain lesions (orbitofrontal cortex, amygdala, etc.) and PSI risk.