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Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells
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Repurposing of Indomethacin and Naproxen as anticancer agents: progress from 2017 to present

Asmaa E Kassab1, Ehab M Gedawy1,2

  • 1Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University Kasr El-Aini Street, P. O. Box 11562 Cairo Egypt asmaa.kassab@pharma.cu.edu.eg +2023635140 +2023639307.

RSC Advances
|December 24, 2024
PubMed

Insights

Non-steroidal anti-inflammatory drugs (NSAIDs) show promise in cancer prevention and therapy by targeting inflammation. This review explores NSAID derivatives, like Indomethacin and Naproxen, for repurposing as anticancer agents.

Area of Science:

  • Oncology
  • Pharmacology
  • Drug Discovery

Background:

  • Inflammation is a key driver in tumor growth and development.
  • Non-steroidal anti-inflammatory drugs (NSAIDs) modulate the tumor microenvironment, enhancing apoptosis and chemosensitivity while reducing cell migration.
  • Drug repurposing offers a faster, cost-effective approach to developing new cancer therapies.

Purpose of the Study:

  • To review the antiproliferative activity of Indomethacin and Naproxen derivatives.
  • To elucidate their mechanisms of action and structural activity relationships (SARs).
  • To assess their potential for repositioning as anticancer agents.

Main Methods:

  • Literature review of studies published between 2017 and 2024.
  • Analysis of antiproliferative effects of NSAID derivatives.
  • Examination of mechanisms of action and SARs.

Main Results:

  • NSAID derivatives exhibit significant antiproliferative activity against various cancer types.
  • Specific structural modifications enhance efficacy and target specific pathways.
  • Established SARs provide a basis for designing more potent anticancer agents.

Conclusions:

  • NSAID derivatives, particularly those of Indomethacin and Naproxen, hold considerable potential for cancer therapy.
  • Drug repurposing of NSAIDs presents a viable strategy for developing novel anticancer treatments.
  • Further research into SARs and clinical trials is warranted for therapeutic deployment.

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