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Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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Related Experiment Video

Updated: Jun 6, 2026

Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees

Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees

Published on: July 15, 2009

Natural potential difference induced functional optimization mechanism for Zn-based multimetal bone implants.

Jing Xu^1,2, Zhenbao Zhang², Jianhui Wang^3,4,5

¹Medical School of Chinese PLA, Beijing, 100039, China.

Bioactive Materials

|December 24, 2024

Summary

This summary is machine-generated.

Innovative additive manufacturing creates Zn/Ti composites for bone implants. This approach accelerates zinc degradation, enhances antibacterial properties, promotes bone growth, and overcomes limitations of current zinc-based biodegradable metals.

Keywords:

Biodegradable metal Bone repair Multi-material additive manufacturing Potential difference Zn/Ti

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Last Updated: Jun 6, 2026

Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees

Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees

Published on: July 15, 2009

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

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Published on: July 1, 2013

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

Published on: December 8, 2015

Area of Science:

Biomaterials Science
Materials Engineering
Orthopedic Surgery

Background:

Zinc-based biodegradable metals (BMs) show promise for bone implants but face challenges with mechanical strength, degradation rate, and zinc ion (Zn2+) toxicity.
Current limitations hinder the widespread clinical application of Zn-BMs.

Purpose of the Study:

To develop a novel Zn/titanium (Ti) hetero-structured composite using multi-material additive manufacturing (MMAM).
To investigate the biodegradation, biofunction, and bone regeneration capabilities of the composite.
To address the limitations of traditional Zn-BMs for orthopedic applications.

Main Methods:

Fabrication of a Zn/Ti hetero-structured composite via MMAM.
Evaluation of galvanic coupling corrosion between Zn and Ti due to a natural potential difference.
Assessment of Zn2+ release, antibacterial activity, and osteogenic differentiation in vitro.
Investigation of in vivo bone regeneration and Zn2+ toxicity mitigation.

Main Results:

A natural potential difference between Zn and Ti accelerated Zn degradation by 2.7 times via galvanic coupling corrosion.
Accelerated Zn2+ release enhanced antibacterial effects and promoted in vitro osteogenic differentiation via the PI3K-Akt pathway.
The composite demonstrated improved in vivo bone regeneration and mitigated overdose Zn2+ toxicity.
MMAM enables specific component deployment for potential functionally graded applications.

Conclusions:

The Zn/Ti composite fabricated by MMAM overcomes key limitations of Zn-BMs.
Galvanic coupling corrosion and generated voltage signals optimize biodegradation and bioactivity.
This approach offers a promising strategy for advanced, functionally graded bone implants.