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A multi-valent polymyxin-based fluorescent probe for the detection of Gram-negative infections
Richa Sharma1, Maria Rodriguez-Rios1, James Crossland1
1School of Chemistry, University of Edinburgh, David Brewster Road, Edinburgh EH9 3FJ, UK.
None:
A multi-branched fluorogenic probe for the rapid and specific detection of Gram-negative bacteria is reported. Three Gram-negative-targeting azido-modified polymyxins were clicked onto a trivalent scaffold functionalised with the environmental green-emitting fluorophore 7-nitrobenz-2-oxa-1,3-diazole. The probe allowed wash-free detection of target bacteria with increased sensitivity and lower limits of detection compared to monovalent probes.
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