Gastroduodenal polyps in familial polyposis coli

Area of Science:

• Gastroenterology
• Oncology
• Genetics

Background:

• Familial polyposis coli (FPC) is an inherited condition characterized by numerous polyps in the colon.
• Extracolonic manifestations are common in FPC, but the upper gastrointestinal tract involvement is less understood.

Purpose of the Study:

• To investigate the incidence and types of gastroduodenal polyps in patients with familial polyposis coli.
• To determine if gastroduodenal polyp occurrence correlates with extracolonic manifestations in FPC patients.

Main Methods:

• Gastroduodenoscopy was performed on 26 patients diagnosed with familial polyposis coli without extracolonic manifestations.
• Histopathological examination of polyps identified were conducted.

Main Results:

• Histologically verified polyps were found in 69% of the examined patients.
• Gastric adenomas, fundic gland polyposis, and duodenal adenomas were diagnosed in 1, 6, and 12 patients, respectively.
• The incidence of gastroduodenal polyps was found to be independent of other extracolonic manifestations.

Conclusions:

• Familial polyposis coli patients have a high incidence of gastroduodenal polyps.
• Upper gastrointestinal screening via gastroduodenoscopy and biopsy is advisable for all patients with familial polyposis coli.