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Old age decreases the risk of lymph node metastasis in T1-2 hypopharynx squamous cell carcinoma patients.

Yujiao Li1,2,3,4,5, Chaosu Hu1,2,3,4,5

  • 1Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital.

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
|December 24, 2024
PubMed
Summary
This summary is machine-generated.

Younger patients with hypopharynx squamous cell carcinoma (SCC) have a higher risk of cervical lymph node metastasis (LNM). This finding highlights the need for tailored treatment strategies for younger individuals to reduce recurrence.

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Area of Science:

  • Oncology
  • Head and Neck Surgery
  • Epidemiology

Background:

  • Cervical lymph node metastasis (LNM) is a critical prognostic indicator in hypopharynx squamous cell carcinoma (SCC).
  • The influence of patient age on LNM risk in early-stage (T1-2) hypopharynx SCC requires further elucidation.

Purpose of the Study:

  • To investigate the association between age and the risk of LNM in patients diagnosed with T1-2 hypopharynx SCC.
  • To identify age-related risk factors for LNM in this patient cohort.

Main Methods:

  • Data from 1018 patients with T1-2 hypopharynx SCC were analyzed from the Surveillance, Epidemiology and End Results (SEER) database (2005-2014).
  • Univariate and multivariate logistic regression models were employed to assess the relationship between age and LNM risk.
  • Hazard ratios (HR) and 95% confidence intervals (CI) were calculated to quantify the risk associated with different age groups.

Main Results:

  • Older patients (≥ 70 years) demonstrated a significantly lower risk of LNM compared to younger patients (P < 0.01).
  • Multivariate analysis confirmed that older age was independently associated with a reduced risk of LNM.
  • Subgroup analysis revealed that older age correlated with increased LNM risk specifically in Caucasian males with moderately/poorly differentiated tumors.

Conclusions:

  • Age is a significant factor influencing LNM risk in T1-2 hypopharynx SCC, with younger patients facing a higher risk.
  • These findings underscore the importance of precise LNM assessment and may inform decisions regarding prophylactic neck treatment in younger patients to mitigate recurrence.