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Ionic Diode-Based Drug Delivery System
Hyunjae Yoo1, Soon-Bo Kang1, Jeongsoo Kim2
1Department of Material Science and Engineering, Seoul National University, Seoul, 08826, Republic of Korea.
Advanced Materials (Deerfield Beach, Fla.)
|December 24, 2024
Summary
A novel ionic diode drug delivery system offers controlled, sustained release of cytotoxic drugs, improving anti-tumor efficacy and reducing toxicity in preclinical models.
Area of Science:
- Biomedical Engineering
- Materials Science
- Oncology
Background:
- Conventional drug delivery systems struggle with spatiotemporally controlled and sustained release of cytotoxic drugs.
- Achieving precise drug release is vital for maximizing efficacy and minimizing off-target tissue damage.
Purpose of the Study:
- To develop and evaluate an electric potential-controlled ionic diode-based drug delivery system for sustained and localized drug release.
- To assess the system's anti-tumor efficacy and safety in a preclinical tumor model.
Main Methods:
- An ionic diode system was engineered for controlled drug release (nanogram to microgram scales) via electric potential.
- The system utilizes a hydrogel for slow, continuous drug diffusion to the target site.
- The device was implanted in a freely moving tumor-bearing mouse model and loaded with doxorubicin.
Main Results:
- The ionic diode system demonstrated sustained, flow-free drug delivery with minimal leakage over extended periods.
- In vivo studies showed superior anti-tumor efficacy of doxorubicin delivered via the system compared to intratumoral injection.
- The system exhibited minimal off-target immune toxicity, highlighting its safety profile.
Conclusions:
- The ionic diode drug delivery system provides a promising platform for controlled and sustained release of cytotoxic agents.
- The system's biocompatible and mechanically compliant nature supports its potential for clinical translation in treating surgically unresectable tumors.
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