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Updated: Jun 4, 2025

Author Spotlight: Enhancing Coronary Artery Revascularization
Published on: September 15, 2023
Arterial conduits for coronary bypass grafting: the set-point concept
Antonio M Calafiore1, Sotirios Prapas1, Mario Gaudino2
1First Department of Cardiac Surgery A, Henry Dunant Hospital, Athens, Greece.
Abstract:
Endothelial cells control the vascular tone of arterial grafts used for coronary artery bypass surgery and react to changes in local shear stress. The vascular adaptations induced by endothelial cell activation affect the outcome of surgical grafts and can be predicted based on the set-point theory. In this Hypothesis piece, it is proposed that the set-point concept should inform surgical decision making for coronary artery bypass surgery.
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