Related Experiment Video
Updated: Apr 12, 2026
07:04
A Step Beyond BRET: Fluorescence by Unbound Excitation from Luminescence FUEL
Published on: May 23, 2014
11.5K
Aggregation-induced emission(AIE)for next-generation biosensing and imaging: A review
Keyi Ren1, Bangjie Zhang2, Jiuchuan Guo3
1School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Biosensors & Bioelectronics
|December 24, 2024
Summary
Aggregation-induced emission (AIE) materials offer sensitive detection for biomedical research. This review details AIE biosensor design and applications, guiding future advancements in fluorescence-turn-on sensing.
Area of Science:
- Materials Science
- Biomedical Engineering
- Analytical Chemistry
Background:
- Luminescence technology is crucial for biomedical research and marker detection.
- Aggregation-induced emission (AIE) materials exhibit unique luminescence properties, including high sensitivity and biocompatibility.
- Existing reviews primarily focus on AIE material design, with limited coverage of biosensor preparation and application strategies.
Purpose of the Study:
- To provide a comprehensive overview of AIE phenomenon, mechanisms, and classic AIE molecules.
- To summarize strategies for luminescence tuning and functionalization of AIE materials.
- To detail the design, preparation, and application of AIE-based biosensors in biosensing and bioimaging.
Main Methods:
- Review of existing literature on AIE phenomenon and AIE materials.
- Analysis of luminescence tuning strategies and functionalization techniques for AIEgens.
- Compilation of working principles and preparation methods for AIE-based biosensors.
Main Results:
- Discussion of the discovery and mechanism of AIE.
- Overview of classic AIE molecules and their luminescence tuning strategies.
- Summary of AIE-based biosensor design, preparation, and typical applications in biosensing and imaging.
Conclusions:
- AIE technology offers significant potential for developing highly sensitive fluorescence-turn-on biosensors.
- This review highlights current limitations and future research directions for AIE in biomedical applications.
- The insights aim to facilitate the rational design of next-generation AIE biosensors for advanced biomedical applications.
Related Concept Videos
01:20Atomic Emission Spectroscopy: Overview
4.4K
Atomic emission spectroscopy (AES) is an analytical technique used to determine the elemental composition of a sample by analyzing the light emitted from excited atoms. In AES, atoms in a sample are excited to higher energy levels by thermal energy from high-temperature sources, such as plasma, arcs, or sparks. When these excited atoms return to lower energy states, they emit light at specific wavelengths characteristic of each element. The resulting atomic emission spectrum, which consists of...
4.4K
01:22Atomic Emission Spectroscopy: Instrumentation
1.6K
The instrumentation of atomic emission spectrometry (AES) involves various components, including atomization devices that convert samples into gas-phase atoms and ions. There are two main types of atomization devices: continuous and discrete atomizers. Continuous atomizers, like plasmas and flames, introduce samples in a constant stream, while discrete atomizers inject individual samples using syringes or autosamplers. The most common discrete atomizer is the electrothermal atomizer.
1.6K
01:26Inductively Coupled Plasma Atomic Emission Spectroscopy: Instrumentation
1.0K
Inductively coupled plasma (ICP) is the common plasma source used in atomic emission spectroscopy (AES), a technique that detects and analyzes various elements in a sample. This method is often called inductively coupled plasma atomic emission spectroscopy (ICP-AES).
There are three main types of inductively coupled plasma atomic emission spectroscopy (ICP-AES) instruments: sequential, simultaneous multichannel, and Fourier transform instruments, with the latter being less commonly used....
There are three main types of inductively coupled plasma atomic emission spectroscopy (ICP-AES) instruments: sequential, simultaneous multichannel, and Fourier transform instruments, with the latter being less commonly used....
1.0K
01:29Atomic Emission Spectroscopy: Lab
835
AES is a powerful analytical technique, especially effective when used with plasma sources, producing abundant spectra in characteristic emission lines. The Inductively Coupled Plasma (ICP), in particular, yields superior quantitative analytical data due to its high stability, low noise, low background, and minimal interferences under optimal experimental conditions. However, newer air-operated microwave sources are emerging as promising alternatives that could be more cost-effective than...
835
01:28Gene Regulation in Microbial Communities: Quorum Sensing
913
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
913
01:17Microbial Biosensors
61
Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...
61