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Ampicillin inhibits biliary cholesterol secretion.

M D Apstein, A R Russo

    Digestive Diseases and Sciences
    |March 1, 1985
    PubMed
    Summary
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    Ampicillin, an antibiotic, was found to inhibit the secretion of phospholipids and cholesterol into bile in rats. This significantly alters bile

    Area of Science:

    • Hepatobiliary physiology
    • Gastroenterology
    • Pharmacology

    Background:

    • Bile composition is influenced by various compounds secreted into bile.
    • Organic anions like bilirubin and BSP reduce biliary phospholipid and cholesterol secretion.
    • The effect of ampicillin on biliary lipid secretion was previously unknown.

    Purpose of the Study:

    • To investigate the impact of ampicillin on biliary lipid secretion.
    • To determine if ampicillin affects bile flow and lipid composition.

    Main Methods:

    • Rats with depleted bile salt pools were infused with taurocholate to stabilize biliary lipid secretion.
    • Ampicillin was administered in a stepwise infusion.
    • Bile flow, biliary ampicillin, phospholipid, and cholesterol secretion were measured.

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    Main Results:

    • Ampicillin infusion increased bile flow and biliary ampicillin secretion.
    • Biliary phospholipid and cholesterol secretion significantly decreased, while bile salt secretion remained unchanged.
    • The lithogenic index of bile decreased.
    • Secretion rates did not change further with increased ampicillin dosage.
    • Upon discontinuation, bile flow and ampicillin secretion decreased, and lipid secretion normalized.

    Conclusions:

    • Ampicillin directly inhibits the biliary secretion of phospholipids and cholesterol.
    • Ampicillin reduces the molar percentage of cholesterol in bile.
    • Ampicillin's effects on biliary lipid composition are dose-independent within the tested range.