Related Experiment Video
Updated: May 5, 2026
Simultaneous EEG Monitoring During Transcranial Direct Current Stimulation
Published on: June 17, 2013
Simultaneous Bilateral T1, T2, and T1ρ Relaxation Mapping of Hip Joint With 3D-MRI Fingerprinting
Anmol Monga1, Hector Lise de Moura1, Marcelo V W Zibetti1
1Center of Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, New York, USA.
Background:
Three-dimensional MR fingerprinting (3D-MRF) has been increasingly used to assess cartilage degeneration, particularly in the knee joint, by looking into multiple relaxation parameters. A comparable 3D-MRF approach can be adapted to assess cartilage degeneration for the hip joint, with changes to accommodate specific challenges of hip joint imaging.
Purpose:
To demonstrate the feasibility and repeatability of 3D-MRF in the bilateral hip jointly we map proton density (PD), T1, T2, T1ρ, and ∆B1+ in clinically feasible scan times.
Study Type:
Prospective.
Subjects:
Eight healthy subjects, three patients with mild osteoarthritis (OA), and one of the OA patients had femoral acetabular impingement (FAI). A National Institute of Standards and Technology/International Society for Magnetic Resonance in Medicine (NIST/ISMRM) system phantom was also used.
Field Strength/Sequence:
3 T, 3D-MRF sequence for bilateral hip joint mapping. Reference sequences include Volume Interpolated Breath-hold Examination (VIBE) for T1 mapping, and magnetization-prepared fast low-angle shot (TFL) for T2 and T1ρ mapping.
Assessment:
The signal-to-noise ratio (SNR), repeatability, scan time, and accuracy of T1, T2, and T1ρ maps of 3D-MRF sequence were evaluated on a NIST/ISMRM phantom and human subjects. Differences in the parametric maps between OA and healthy subjects were assessed.
Statistical Tests:
Regression, Bland-Altman, Kruskal-Wallis, and Wilcoxon tests were used to assess for accuracy, repeatability, and subregional variation. The P-value <0.05 indicated statistically significant.
Results:
A 3D-MRF sequence sensitive to PD, T1, T2, T1ρ, and ∆B1+ within 15 minutes, achieving high SNR and low test-retest coefficient of variance (T1: 3.36%, T2: 3.99%, T1ρ: 5.93%). Mild hip OA patients, including one with mild OA and FAI, showed elevation of 29.4 ± 9% (T2) and 32.4 ± 4.4% (T1ρ) in femoral lateral compartment of the hip joint compared to healthy controls.
Data Conclusion:
3D-MRF may be a feasible approach for simultaneous, quantitative mapping of bilateral hip joint cartilage in healthy and mild OA patients.
Evidence Level:
1 TECHNICAL EFFICACY: Stage 1.
