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Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers

Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers

Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...

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Related Experiment Video

Updated: May 8, 2025

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Published on: September 18, 2013

Case 332: Tyrosine Kinase Inhibitor-induced Intestinal Lymphangiectasia.

Cameron Adler¹, Christine Menias¹

¹From the Department of Radiology, Mayo Clinic Arizona, 5777 E Mayo Blvd, Phoenix, AZ 85054.

|December 24, 2024

Summary

This summary is machine-generated.

This case study details a patient with recurrent sarcomatoid renal cell carcinoma treated with pazopanib and stereotactic radiation. Surveillance imaging revealed disease progression despite treatment.

Area of Science:

Oncology
Medical Imaging

Background:

A 65-year-old male with a history of sarcomatoid renal cell carcinoma and prior nephrectomy presented with recurrent disease.
The patient received maximum-dose pazopanib and palliative stereotactic body radiation therapy (SBRT).

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