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Not So Fast: Intermittent Fasting Fails to Improve Metabolic Flexibility in Mice With Obesity and Type 2 Diabetes

Meghan O Conn1,2,3, Daniel M Marko1,2,3, Jonathan D Schertzer1,2,3

  • 1Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.

Physiology (Bethesda, Md.)
|December 24, 2024
PubMed
Abstract

No abstract available in PubMed .

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Metabolic States of the Body: Fasting and Starvation01:24

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During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
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The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
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