Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

3.3K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.3K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

3.6K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.6K
Aging01:26

Aging

21
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
21
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.0K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.0K
Menopause01:28

Menopause

94
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
94
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

16
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
16

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Twelve-Week Group-Based Exercise and Nutrition Programs: Feasibility and Preliminary Health Improvements in Disabilities.

Geriatrics & gerontology international·2026
Same author

Urolithin A activates mitophagy via the AMPK-mTOR axis and modulates the gut-ceramide axis to ameliorate cardiac remodeling in HFpEF.

Experimental & molecular medicine·2026
Same author

Impact of Combined Frailty and Sarcopenia on Postoperative Outcomes and Survival in Elderly Gastric Cancer Patients Undergoing Gastrectomy.

Journal of gastric cancer·2026
Same author

Psychiatric Safety Signals of GLP-1 Receptor Agonists: A FAERS-Based Pharmacovigilance Study with Explainable Machine Learning.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Nuclear Enlargement as a Histological Hallmark of Skeletal Muscle Aging, Revealed by Deep Learning-Driven Analysis and Validated in Inflammatory Myopathies.

Aging cell·2026
Same author

Ion-coupled transfersome complexes for enhanced transdermal NAD<sup>+</sup> repletion and mitigation of cellular senescence signatures.

Materials today. Bio·2026

Related Experiment Video

Updated: May 8, 2025

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
04:23

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

176

Higher Circulating Resistin Levels Linked to Increased Sarcopenia Risk in Older Adults.

Mi Kyung Kwak1, Ji Yeon Baek2, So Jeong Park3

  • 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Gyeonggi-do 18450, South Korea.

The Journal of Clinical Endocrinology and Metabolism
|December 24, 2024
PubMed
Summary

Higher blood resistin levels are linked to sarcopenia, low muscle mass, and muscle weakness in older adults. This suggests resistin may be a biomarker for poor muscle health.

Keywords:
adipokineagingbiomarkerresistinsarcopenia

More Related Videos

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
13:35

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos

Published on: March 21, 2021

10.3K
Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

12.5K

Related Experiment Videos

Last Updated: May 8, 2025

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
04:23

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

176
Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
13:35

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos

Published on: March 21, 2021

10.3K
Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

12.5K

Area of Science:

  • Gerontology
  • Metabolic Research
  • Biomarker Discovery

Background:

  • Resistin, an adipokine, is known to negatively impact muscle metabolism and myogenesis.
  • Understanding resistin's role in muscle health is crucial for addressing age-related decline.

Purpose of the Study:

  • To investigate resistin as a potential biomarker for muscle health in humans.
  • To examine the association between circulating resistin levels and sarcopenia in older adults.

Main Methods:

  • A case-control study involving 247 individuals aged 65+ in a geriatric clinical unit.
  • Sarcopenia was defined using Asian-specific thresholds.
  • Serum resistin concentrations were measured via enzyme-linked immunosorbent assay (ELISA).

Main Results:

  • Individuals with sarcopenia had significantly higher resistin levels (27.0%+ higher).
  • Elevated resistin was inversely associated with muscle mass, gait speed, and physical performance.
  • Higher resistin levels correlated with increased risk of sarcopenia and adverse muscle outcomes.

Conclusions:

  • A significant link exists between blood resistin levels and sarcopenia in older adults.
  • Circulating resistin shows potential as a biomarker for assessing muscle health.
  • Further research can explore resistin's therapeutic implications for muscle-related conditions.