Related Experiment Video
Updated: Jun 4, 2025
Acetylcholine Re-Challenge After Intracoronary Nitroglycerine Administration
Published on: April 4, 2022
Acupuncture for angina post percutaneous coronary intervention: a protocol for systematic review and meta-analysis
Xin Zhou1, Yanwei Li2, Yongjun Yin3
1School of Acupuncture-Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Insights
This systematic review evaluates acupuncture for angina post percutaneous coronary intervention (PCI). It aims to determine if acupuncture is a safe and effective treatment for this condition.
Area of Science:
- Cardiovascular Medicine
- Integrative and Complementary Medicine
Background:
- Ischaemic heart disease (IHD) is a major cardiovascular condition treated with percutaneous coronary intervention (PCI).
- Angina post PCI (APPCI) significantly impacts patient quality of life and prognosis.
- Current treatment options for APPCI are limited, highlighting the need for effective alternatives.
Purpose of the Study:
- To systematically evaluate the efficacy and safety of acupuncture for preventing and treating APPCI.
- To synthesize evidence from randomized controlled trials (RCTs) on acupuncture's role in managing APPCI.
Main Methods:
- A comprehensive literature search will be conducted across multiple databases (PubMed, Embase, Cochrane Library, etc.) up to June 8, 2024.
- Two independent reviewers will screen studies, extract data, and assess the risk of bias in RCTs.
- Data synthesis and analysis will utilize RevMan V.5.4 software, with subgroup and sensitivity analyses planned.
Main Results:
- This section is to be populated upon completion of the systematic review and data analysis.
- The review will assess the quality of evidence using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system.
Conclusions:
- This systematic review will provide an evidence-based assessment of acupuncture for APPCI.
- Findings will inform clinical recommendations regarding the use of acupuncture in managing patients with APPCI.
Introduction:
Ischaemic heart disease (IHD) is a pathological process characterised by a blockage or non-obstructive accumulation of atherosclerotic plaques in the epicardial arteries. Percutaneous coronary intervention (PCI) is widely used in clinical practice to treat IHD. However, angina post PCI (APPCI) impairs quality of life and portends a worse prognosis. Hence, an effective and safe treatment option remains an urgent need for patients with APPCI. In recent years, there has been an increasing body of clinical trials regarding the use of acupuncture for the prevention and treatment of APPCI, and the results have indicated it might be a promising therapeutic intervention. However, to our knowledge, the potential benefits of acupuncture for the prevention and treatment of APPCI to justify either their recommendation or their clinical role have not been evaluated.
Methods And Analysis:
PubMed, Embase, Cochrane Library, Web of Science Core Collection, Chinese Biomedical Database, Chinese National Knowledge Infrastructure, Wanfang Database and VIP Database will be searched from inception to 8 June 2024 without language restrictions. Two investigators will independently screen studies, extract data, assess the risk of bias from randomised controlled trials (RCTs) and assess the risk of bias. The third reviewer will arbitrate any disagreements. Data synthesis and analysis will be conducted using the RevMan V.5.4 software. Subgroup analyses, sensitivity analysis, meta-regression and bias reporting assessments will be performed if necessary and appropriate. Finally, the quality of evidence from RCTs will be assessed using the Grading of Recommendations Assessment, Development, and Evaluation System tool.
Ethics And Dissemination:
Ethical approval is unnecessary since no private or confidential patient data will be included. The systematic review will be published in peer-reviewed journals.
Prospero Registration Number:
CRD42024562116.
Related Concept Videos
01:16Antianginal Drugs: Nitrates and β-Blockers
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
01:25Antianginal Drugs: Calcium Channel Blockers and Ranolazine
CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...