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Reduction in Antibiotic Usage and Financial Savings Through a Large System Intervention Project.

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|December 25, 2024
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Summary

A large system intervention significantly reduced antibiotic use in newborns at risk for Early Onset Sepsis (EOS). This approach lowered antibiotic exposure by 64% and saved costs, with no increase in EOS readmissions.

Keywords:
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Area of Science:

  • Neonatal Medicine
  • Infectious Disease Prevention
  • Healthcare System Improvement

Background:

  • Infants at risk for Early Onset Sepsis (EOS) often receive antibiotics, leading to potential adverse effects.
  • There is a clinical need to reduce antibiotic exposure in newborns while maintaining safety.

Purpose of the Study:

  • To implement and evaluate a large system intervention (LSI) aimed at decreasing antibiotic usage in at-risk newborns.
  • To assess the impact of the LSI on the proportion of infants exposed to antibiotics.
  • To determine the financial implications of the intervention.

Main Methods:

  • A retrospective analysis of antibiotic use in infants born ≥ 35 weeks gestation from January 2018 to June 2020.
  • Implementation of LSIs, including the Kaiser Sepsis Calculator, between January and June 2019.
  • Comparison of quality metrics 12 months before and after the intervention.

Main Results:

  • Antibiotic usage decreased by 68% and infant exposure decreased by 64% post-intervention.
  • A cost saving of $697 per at-risk newborn was observed.
  • No readmissions for EOS occurred during the study period.

Conclusions:

  • A systemic LSI can be safely implemented to reduce antibiotic exposure in newborns.
  • This intervention demonstrates significant cost savings without compromising patient safety regarding EOS.