Focused Electric Field Technology: A Novel Myoelectrical Stimulation Technology for Noninvasive Aging Muscle...

Myoelectrical stimulation improves muscle function and reduces muscle atrophy and aging. However, research on the mechanism underlying its cosmetic effect remains limited.

The aim of this study was to evaluate the cosmetic effects of the myoelectrical stimulation provided by the wearable intelligent flexible beauty device and its focused electric field technology (FEFT) on facial skin and muscle rejuvenation.

We conducted a single-blind, randomized, self-controlled clinical efficacy experiment on 31 female volunteers using the device. Using an FEFT-based platform, mice with d-galactose-induced skeletal muscle aging were subjected to surface myoelectrical stimulation of the gastrocnemius. Immunohistochemical analysis of skeletal muscles and protein immunoblotting were used to analyze the effects of FEFT.

After 14 days of use, facial skin elasticity significantly increased, wrinkle firmness significantly decreased, and the lift height of the upper eyelid and eye corner angle significantly increased in the volunteers. Clinical evaluation showed improvements in the drooping of the upper eyelid and eye bags. Self-evaluation questionnaires indicated alleviation of facial wrinkles. These improvements were more pronounced after 28 days. In mice, FEFT alleviated aging-induced muscle fiber atrophy, muscle fiber cross-sectional area reduction, and muscle satellite cell loss. FEFT also increased the expression of myogenic factors, including myogenic differentiation 1 (MYOD1).

FEFT exerted a skin-tightening effect by initiating myogenic processes and increasing the transformation of muscle satellite cells. Our research promotes the development of FEFT-based medical rehabilitation or cosmetic anti-aging products and provides a foundation for further application and comprehensive efficacy evaluation in human clinical settings.