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Glial Cells

Glial Cells

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Related Experiment Video

Updated: Jun 4, 2025

Dissection and Isolation of Murine Glia from Multiple Central Nervous System Regions

Dissection and Isolation of Murine Glia from Multiple Central Nervous System Regions

Published on: June 4, 2020

Multiple Sclerosis: Glial Cell Diversity in Time and Space.

Susanne M Kooistra¹, Lucas Schirmer^2,3,4,5

¹Department of Biomedical Sciences, Section Molecular Neurobiology, University of Groningen and University Medical Center Groningen (UMCG), Groningen, The Netherlands.

|December 25, 2024

Summary

This summary is machine-generated.

Glial cells drive multiple sclerosis (MS) lesion progression. Understanding diverse glial subtypes and their dynamic changes is key to developing new MS therapies targeting specific cell types.

Keywords:

astrocytes demyelination microglia neuroinflammation oligodendrocytes

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Last Updated: Jun 4, 2025

Dissection and Isolation of Murine Glia from Multiple Central Nervous System Regions

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Published on: June 4, 2020

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

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An Ex vivo Model of an Oligodendrocyte-directed T-Cell Attack in Acute Brain Slices

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Published on: February 5, 2015

Area of Science:

Neuroimmunology
Central Nervous System Pathology

Background:

Multiple sclerosis (MS) is a prevalent inflammatory disease of the central nervous system.
Demyelination and glial scar formation are hallmarks of MS pathology.
Glial cells, including microglia, oligodendrocytes, and astrocytes, are central to MS lesion progression, influencing both damage and repair.

Purpose of the Study:

To review recent developments in glial cell diversity in MS.
To summarize key findings on the pathological and maladaptive functions of disease-associated glial subtypes.
To highlight the spatial and temporal dynamics of glial cells during MS lesion progression.

Main Methods:

Review of recent high-dimensional findings.
Analysis of epigenomic, transcriptomic, and metabolic features of glial cells.
Focus on spatial and temporal dynamics of glial subtypes in MS lesions.

Main Results:

Glial cells exhibit significant diversity and dynamic changes in MS.
Specific glial subtypes play critical roles in lesion progression, contributing to both damage and repair.
Epigenomic, transcriptomic, and metabolic alterations are observed in glial cells across MS lesions.

Conclusions:

Detailed understanding of spatially restricted glial subtype functions is crucial for MS research.
Knowledge of glial cell dynamics is essential for understanding MS pathogenesis.
Targeting specific glial cell types holds promise for developing novel MS therapies.