Evaluating hemodynamic response to treatment in patients with peripheral arterial disease using dynamic vascular...

Tracking changes in the vasculature of patients with peripheral arterial disease (PAD) may identify the need for follow-up treatment within only weeks after an initial intervention, enabling timely support and improving patient outcomes.

We aim to evaluate dynamic vascular optical spectroscopy's (DVOS's) ability to accurately monitor the hemodynamics of affected arteries in patients with PAD after a surgical intervention and predict long-term clinical outcomes.

A DVOS system non-invasively monitored the blood flow through 256 lower extremity arteries in 80 PAD patients immediately before, immediately after, and 3 to 4 weeks after they underwent a surgical intervention.

Hemodynamic changes measured by DVOS after a revascularization procedure (RP) classified patient long-term ( $6.2\pm 4.4$ months) outcomes with high accuracy [81.6% for patients with ulcers ( $n=31$ ); 81.1% for patients without ulcers ( $n=54$ )] by 3 to 4 weeks after the RP, outperforming available ankle-brachial index and ultrasound measurements. In addition, DVOS parameters distinguished between patients who underwent only a catheter angiography (CA) and patients who underwent both a CA and RP ( $P<0.05$ ).

The DVOS system was able to classify patient long-term clinical outcomes with high accuracy within one month after an RP and distinguish among different interventions. DVOS may be a promising alternative or adjunct to existing monitoring approaches.