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Updated: May 8, 2025

Computational Analysis of the Caenorhabditis elegans Germline to Study the Distribution of Nuclei, Proteins, and the Cytoskeleton
Published on: April 19, 2018
Mechano-regulation of germline development, maintenance, and differentiation
Ishani Sharma1, Anup Padmanabhan1
1Department of Biology, Trivedi School of Biosciences, Ashoka University, No. 2 Rajiv Gandhi Educational City, Sonipat, Haryana 131029, India.
Abstract:
Biochemical signaling arising from mechanical force-induced physical changes in biological macromolecules is a critical determinant of key physiological processes across all biological lengths and time scales. Recent studies have deepened our understanding of how mechano-transduction regulates somatic tissues such as those in alveolar, gastrointestinal, embryonic, and skeleto-muscular systems. The germline of an organism has a heterogeneous composition - of germ cells at different stages of maturation and mature gametes, often supported and influenced by their accessory somatic tissues. While biochemical signaling underlying germline functioning has been extensively investigated, a deeper interest in their mechanical regulation has been gaining traction in recent years. In this review, we delve into the myriad ways in which germ cell development, maintenance, and functions are regulated by mechanical forces.
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