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Related Experiment Video

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Tracing Sentinel Lymph Nodes and Inhibiting Lymphatic Metastasis with TiN Nanobipyramids Through Photothermal

Yan-Neng Xu1, Xiaopeng Bai2, Jian-Li Chen3

  • 1State Key Laboratory of Quality Research in Chinese Medicines, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, 999078, People's Republic of China.

International Journal of Nanomedicine
|December 25, 2024
PubMed
Summary

Titanium nitride nanobipyramids offer dual imaging and photothermal ablation for sentinel lymph node mapping and metastasis inhibition. This novel theranostic approach improves cancer staging and treatment outcomes.

Keywords:
TiN nanobipyramidslymph node mappingphotothermal therapysecond near-infrared windowsentinel lymph nodes

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Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Oncology

Background:

  • The lymphatic system is a primary route for cancer metastasis, with sentinel lymph nodes (SLNs) being the initial site of cancer cell spread.
  • Accurate SLN identification is critical for surgical staging (biopsy, lymphadenectomy), but current tracers like blue dyes and carbon nanoparticles have limitations.
  • There is a need for advanced SLN imaging agents with theranostic capabilities to improve cancer treatment.

Purpose of the Study:

  • To synthesize large-sized titanium nitride nanobipyramids (TiN NBPs) for multimodal SLN mapping.
  • To investigate the potential of TiN NBPs as both imaging agents and therapeutic tools for cancer metastasis.

Main Methods:

  • TiN NBPs were synthesized using a hydrothermal method followed by post-nitridation treatment.
  • The NBPs were evaluated for SLN tracing using bright- and dark-field imaging.
  • The efficacy of TiN NBP-based photothermal ablation of lymph nodes, combined with primary tumor removal, was assessed for inhibiting pulmonary metastasis.

Main Results:

  • TiN NBPs demonstrated dual bright- and dark-field imaging capabilities, showing effective lymph node drainage for SLN tracing.
  • The TiN NBPs exhibited high photothermal conversion efficiency under 1064 nm laser irradiation due to their plasmonic properties.
  • Combined photothermal ablation of metastatic lymph nodes in the second near-infrared window (NIR-II) and primary tumor removal significantly inhibited pulmonary metastasis.

Conclusions:

  • TiN NBPs represent a novel tracer for SLN mapping, offering improved visualization and diagnostic potential.
  • This study presents a promising theranostic strategy utilizing TiN NBPs for photothermal ablation of lymph nodes in the NIR-II window to combat lymphatic metastasis.