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Updated: Jul 17, 2026

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Published on: March 6, 2014
Non-progressive CRMP-5-Associated Perifoveal Retinopathy in a Breast Cancer Patient: A Rare Paraneoplastic Phenomenon
Isabella Canut1, Rachel Bielling2, Fiona Steinmetz2
1Neurology, Philadelphia College of Osteopathic Medicine, Suwanee, USA.
Abstract:
Paraneoplastic retinopathy (PR) is a rare autoimmune condition typically associated with progressive visual loss and is often linked to anti-recoverin antibodies. Paraneoplastic optic neuropathy (PON) is classically associated with collapsin response-mediator protein (CRMP-5). We present a unique case of non-progressive CRMP-5-associated perifoveal retinitis in a 79-year-old female with a history of breast carcinoma, who has maintained a stable visual acuity over an extended follow-up period of three years.
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