Related Experiment Video
Updated: May 8, 2025

Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis
Published on: July 18, 2017
Legionnaires' Disease Presenting With Acute Kidney Injury: Successful Treatment With Antibiotics
Ai Fujii1, Mizuki Mishima2, Sho Kumano2
1Nephrology, Kanazawa Medical University, Kahoku, JPN.
Abstract:
Legionnaires' disease is a bacterial infection caused by Legionella, such as Legionella pneumophila. It mainly causes severe pneumonia, with symptoms such as fever, cough, and shortness of breath. In rare cases, it can cause acute kidney disease and also occasionally become severe enough to require replacement therapy. We report the case of a patient who was admitted with severe pneumonitis and acute kidney injury following Legionella infection. Symptoms improved with antibiotic treatment; however, renal damage persisted. A renal biopsy was performed, highlighting the importance of recognizing kidney involvement in Legionella infections and demonstrating how renal biopsy can guide the course of treatment.
Related Concept Videos
Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Nephrons
Dialysis
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Tonsillitis II: Management
Acute Respiratory Failure-V
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...

