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Diabetic ulcer with cutaneous squamous cell carcinoma: A case report
Yun Luo1, Chen-Ying Li2, Yu-Qing Wang1
1Department of Vascular Surgery in Traditional Chinese Medicine, Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200082, China.
World Journal of Clinical Oncology
|December 25, 2024
Summary
Chronic skin ulcers, especially in diabetic patients, can develop into squamous cell carcinoma. Early detection and surgical removal of these nonhealing wounds are crucial for preventing malignancy.
Area of Science:
- Oncology
- Dermatology
- Diabetology
Background:
- Chronic skin ulcers are recognized risk factors for developing skin tumors.
- Diabetic patients with chronic, nonhealing ulcers face increased susceptibility to skin malignancies.
- Prompt surgical intervention for diabetic foot ulcers can prevent progression to squamous cell carcinoma.
Observation:
- An 84-year-old male with diabetes presented with a chronic foot ulcer present since 1996.
- Despite various treatments between 2012 and 2019, the ulcer remained nonhealing.
- Histopathological analysis in July 2020 confirmed well-differentiated cutaneous squamous cell carcinoma.
Findings:
- The chronic diabetic foot ulcer was diagnosed as squamous cell carcinoma.
- Post-treatment, the ulcer wound showed slow healing without expansion.
- The case highlights potential misdiagnosis due to insufficient clinical evidence for malignant transformation in chronic ulcers.
Implications:
- Enhancing clinical awareness of malignant potential in chronic ulcer wounds is critical.
- Timely identification and treatment of potentially malignant lesions in chronic ulcers are essential for preventing cancer progression.
- This case underscores the importance of vigilant monitoring and histopathological evaluation of persistent diabetic foot ulcers.
