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Mucoadhesive Enhancement of Gelatine by Tannic Acid Crosslinking for Buccal Application

  • 0Faculty of Pharmacy, Universiti Teknologi MARA, Selangor Branch, Puncak Alam Campus, Puncak Alam, Selangor, Malaysia.
Biopolymers +

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December 25, 2024

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December 25, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Tannic acid-crosslinked gelatine (GelTA) films offer enhanced mucoadhesion and extended drug release for buccal delivery. Optimized bovine GelTA films show promise for improved drug delivery systems.

Area Of Science

  • Materials Science
  • Pharmaceutical Sciences
  • Biomaterials Engineering

Background

  • Gelatine-based films are explored for buccal drug delivery.
  • Mucoadhesive properties and controlled dissolution are crucial for buccal matrices.
  • Tannic acid crosslinking offers a potential method to enhance gelatine film properties.

Purpose Of The Study

  • To evaluate formulation parameters impacting tannic acid-crosslinked gelatine (GelTA) films for buccal drug delivery.
  • To optimize GelTA films for mucoadhesion, dissolution, and drug release characteristics.
  • To characterize GelTA films for their potential as extended buccal drug delivery matrices.

Main Methods

  • Solvent evaporation technique used for GelTA film preparation.
  • Screening based on mucoadhesion and dissolution characteristics.
  • Formulation variables: gelatine source, tannic acid concentration, pH, and plasticisers.

Main Results

  • GelTA films showed significantly improved dissolution times compared to non-crosslinked films.
  • Optimized bovine GelTA film (BG-GLY20-7) demonstrated 1.6-fold increased mucoadhesivity and 6-hour dissolution time.
  • Enhanced antioxidant and antimicrobial properties were observed in optimized GelTA films.
  • Stability studies indicated a need for storage in an oxygen-free environment.

Conclusions

  • Tannic acid-crosslinked gelatine films are promising for buccal drug delivery.
  • Optimized GelTA films offer extended dissolution, substantial water uptake, and enhanced adhesive strength.
  • Further research on storage conditions is recommended for clinical application.

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