Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Bacterial Signaling01:30

Bacterial Signaling

31.5K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
31.5K
Biological Methods for Microbial Control01:28

Biological Methods for Microbial Control

Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

1
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
1
Defense Mechanism Against Infection01:26

Defense Mechanism Against Infection

6.4K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
6.4K
Antimicrobial Proteins01:23

Antimicrobial Proteins

893
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
893

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multiphasic lipid nanoparticles: structural heterogeneity drives endosomal bypass for enhanced RNA delivery.

Journal of colloid and interface science·2026
Same author

Ethanol-Guided Hybridization of Extracellular Vesicles with Liquid-Crystalline Lipid Nanoparticles.

ACS applied materials & interfaces·2026
Same author

A Bioinspired Mastoparan Exhibits Concentration-Dependent Anti-Bacterial Activity via Membrane Disruption.

ACS applied materials & interfaces·2025
Same author

Cultivating choices: A photovoice study exploring lived experiences of food environments for vegetable-rich diets across Fiji's rural-urban gradient.

Health & place·2025
Same author

Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery.

Journal of visualized experiments : JoVE·2025
Same author

Non-invasive tape sampling of tryptophan and kynurenine in relation to phenylalanine and tyrosine from melanoma and adjacent non-lesional skin: A pilot study.

PloS one·2025

Related Experiment Video

Updated: Jun 4, 2025

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
08:08

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

22.0K

Combining functionalities-nanoarchitectonics for combatting bacterial infection.

Lucrezia Caselli1, Martin Malmsten2

  • 1Physical Chemistry 1, University of Lund, S-221 00 Lund, Sweden.

Advances in Colloid and Interface Science
|December 25, 2024
PubMed
Summary
This summary is machine-generated.

New nanoparticle (NP) surface modifications enhance antimicrobial efficacy and reduce human cell toxicity. These targeted NPs offer a promising strategy against antibiotic-resistant bacteria and associated inflammation.

Keywords:
BacteriaNanoarchitectonicsNanoparticleTargeting

More Related Videos

Focused Ion Beam Lithography to Etch Nano-architectures into Microelectrodes
13:49

Focused Ion Beam Lithography to Etch Nano-architectures into Microelectrodes

Published on: January 19, 2020

6.7K
Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
11:52

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

3.0K

Related Experiment Videos

Last Updated: Jun 4, 2025

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
08:08

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

22.0K
Focused Ion Beam Lithography to Etch Nano-architectures into Microelectrodes
13:49

Focused Ion Beam Lithography to Etch Nano-architectures into Microelectrodes

Published on: January 19, 2020

6.7K
Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
11:52

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

3.0K

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Infectious Disease Research

Background:

  • Antibiotic resistance necessitates novel antimicrobial and anti-inflammatory therapeutics.
  • Nanoparticles (NPs) show promise but suffer from poor selectivity, causing adverse effects.
  • Targeting strategies are crucial to enhance NP efficacy and safety.

Purpose of the Study:

  • To review surface modification strategies for targeting bacterial membranes with nanomaterials.
  • To discuss how these modifications improve antimicrobial effects and reduce human cell toxicity.
  • To correlate observed biological effects with underlying physico-chemical mechanisms.

Main Methods:

  • Literature review of nanoparticle surface modification techniques.
  • Analysis of strategies for bacterial membrane recognition and targeting.
  • Examination of NP conjugation with peptides, proteins, nucleic acids, and enzyme substrates.
  • Discussion of physico-chemical modes of action.

Main Results:

  • Surface modifications enable targeted recognition of bacterial membranes and components.
  • Targeted NPs demonstrate enhanced antimicrobial activity against resistant strains.
  • Improved selectivity significantly reduces toxicity towards human cells and tissues.
  • Physico-chemical properties dictate the biological effects and therapeutic potential.

Conclusions:

  • Surface-modified nanomaterials offer a viable approach to combat antibiotic resistance.
  • Targeting strategies are key to developing safe and effective nanotherapeutics.
  • Understanding mechanisms of action is vital for optimizing NP design and application.