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A prospective, historical-controlled evaluation of oliceridine for moderate or severe pain in patients with acute burn injuries (RELIEVE)

  • 0Department of Pharmacy, Regional One Health, Firefighter's Burn Center, Regional One Health, 877 Jefferson Avenue, Memphis, TN 38103, USA.
Burns : Journal of the International Society for Burn Injuries +

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December 25, 2024

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December 25, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Oliceridine provided superior pain relief in burn patients compared to standard opioids. This novel analgesic demonstrated sustained efficacy over seven days with no unexpected adverse events.

Area Of Science

  • Pharmacology
  • Pain Management
  • Burn Injury Treatment

Background

  • Oliceridine is a biased opioid agonist with preferential G-protein activation over β-arrestin.
  • β-arrestin pathway activation is linked to adverse events like constipation and respiratory depression.
  • Limited data exists on oliceridine's use in acute burn injury patients.

Purpose Of The Study

  • To evaluate the efficacy and safety of oliceridine for analgesia in acute burn injury.
  • To compare oliceridine's pain relief to standard opioid care in burn patients.

Main Methods

  • A prospective study of ten burn patients receiving oliceridine as sole opioid for up to 7 days.
  • Comparison with a matched historical cohort receiving standard opioids (fentanyl, oxycodone, hydromorphone, morphine).
  • Pain scores (Numerical Rating Scale) and opioid consumption (Morphine Milligram Equivalents) were analyzed.

Main Results

  • Both groups showed decreased pain scores over 7 days, but oliceridine achieved a significantly greater reduction.
  • Oliceridine use was associated with a statistically significant larger decrease in mean pain score.
  • No significant difference in average daily morphine milligram equivalents was observed between groups.
  • No unexpected adverse events were reported with oliceridine.

Conclusions

  • Oliceridine demonstrated significant and sustained pain relief in acute burn injury patients.
  • The novel opioid offers a potentially safer alternative for managing burn-related pain.
  • Further research is warranted to confirm these findings in larger cohorts.

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