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Staphylococcus aureus skin colonization in atopic dermatitis patients.

C Hauser, B Wuethrich, L Matter

    Dermatologica
    |January 1, 1985
    PubMed
    Summary

    Patients with atopic dermatitis (AD) show significantly higher Staphylococcus aureus skin colonization on both normal and lesional skin compared to healthy individuals. This increased S. aureus burden has implications for AD management and infection control.

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    Area of Science:

    • Dermatology
    • Microbiology
    • Epidemiology

    Background:

    • Atopic dermatitis (AD) is a chronic inflammatory skin condition.
    • Skin colonization by Staphylococcus aureus is common in AD patients.
    • The extent and distribution of S. aureus colonization in AD require further investigation.

    Purpose of the Study:

    • To compare Staphylococcus aureus skin colonization levels in patients with atopic dermatitis (AD) versus healthy controls.
    • To quantify S. aureus density on different types of AD skin lesions.
    • To assess the antibiotic sensitivity of S. aureus strains isolated from AD patients.

    Main Methods:

    • Quantification of total aerobe and Staphylococcus aureus counts (CFU/cm2) on skin.
    • Comparison of colonization between AD patients (n=21) and healthy controls (n=22).

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  • Isolation and antibiotic sensitivity testing of S. aureus strains from lesional skin.

    • Main Results:

    • Significantly higher total aerobe counts, S. aureus fraction, and carrier frequency in AD patients' normal skin.
    • S. aureus density was 100-1,000 times higher on dermatitic, lichenified, and impetiginized skin compared to normal AD skin.
    • Antibiotic sensitivity of 190 S. aureus strains to 5 topical antibiotics was determined.

    Conclusions:

    • Atopic dermatitis patients exhibit markedly increased Staphylococcus aureus skin colonization.
    • Severe S. aureus colonization on lesional skin poses biological and epidemiological risks.
    • Findings support the need for preventive and therapeutic strategies targeting S. aureus in AD.