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Updated: May 8, 2025

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

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Published on: August 21, 2017

Co-occurrence of Neuromyelitis Optica Spectrum Disorder and Idiopathic Multicentric Castleman Disease Successfully

Takuma Tsuzuki Wada¹, Kazuhiro Yokota¹, Mariko Okada²

¹Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan.

Internal Medicine (Tokyo, Japan)

|December 25, 2024

Abstract:

We herein report a 52-year-old woman with anti-aquaporin 4 antibody-positive neuromyelitis optica spectrum disorder (NMOSD) and idiopathic multicentric Castleman disease (iMCD) who was successfully treated with tocilizumab, a humanized anti-human interleukin (IL)-6 receptor monoclonal antibody. This is the first report of a case of coexisting NMOSD and iMCD. IL-6 is involved in the pathogenesis of both NMOSD and iMCD, and tocilizumab is effective against both diseases. By treating the patient with tocilizumab, the lung lesions due to iMCD improved, and the neurological symptoms of NMOSD did not recur.

Keywords:

Castleman disease interleukin-6 neuromyelitis optica spectrum disorder tocilizumab

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Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
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Keywords:

Castleman disease interleukin-6 neuromyelitis optica spectrum disorder tocilizumab

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