[A Case of Pathological Complete Response after Nivolumab Therapy in Unresectable Advanced Gastric Cancer]

Rei Ogura1, Kazuhiro Migita, Ayumi Nishioka

  • 1Dept. of Surgery, Nara Prefecture General Medical Center.

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Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
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