Related Experiment Video
Updated: Jun 4, 2025
04:49
Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
Published on: May 16, 2025
77
Preclinical RA: How to halt its progression.
Tong Wu1, Yanhong Li1, Yi Liu2
1Department of Rheumatology and Immunology, Laboratory of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Best Practice & Research. Clinical Rheumatology
|December 25, 2024
Summary
This review details rheumatoid arthritis (RA) progression from genetic and environmental factors to preclinical autoimmunity. Early interventions targeting preclinical RA may prevent disease onset.
Area of Science:
- Immunology
- Rheumatology
- Autoimmune Diseases
Background:
- Rheumatoid arthritis (RA) is a chronic autoimmune disease with a complex, multi-stage pathogenesis.
- Disease progression involves genetic predisposition, environmental triggers, and preclinical autoimmunity before clinical symptoms.
Purpose of the Study:
- To review the natural history of rheumatoid arthritis.
- To highlight opportunities for intervention during preclinical stages.
Main Methods:
- Literature review of rheumatoid arthritis pathogenesis.
- Analysis of genetic and environmental factors contributing to RA development.
Main Results:
- Autoantibodies like anti-citrullinated protein antibodies (ACPA) and rheumatoid factor precede clinical RA by years.
- Preclinical autoimmunity is a critical window for potential disease interception.
Conclusions:
- Understanding RA's natural history is key to developing preventive strategies.
- Interventions such as lifestyle changes and immune modulation may halt progression in at-risk individuals.
Related Concept Videos
01:20The JAK-STAT Signaling Pathway
8.7K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.7K
01:24T Cell Types and Functions
947
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
947
02:07Tumor Progression
6.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K
01:38Inflammation
52.5K
Overview
52.5K