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Elevated serum and antral gastrin in obese (ob/ob) mice
Gastroenterology
|April 1, 1985
Summary
Obese mice exhibit significantly elevated serum gastrin levels, a condition not caused by overeating. This hypergastrinemia may stem from reduced stomach acid inhibiting gastrin release.
Area of Science:
- Endocrinology
- Gastroenterology
- Obesity Research
Background:
- Obesity is associated with various metabolic and physiological changes.
- Gastrin plays a crucial role in regulating gastric acid secretion and mucosal growth.
Purpose of the Study:
- To investigate serum gastrin concentrations in obese mice.
- To explore the relationship between obesity, gastrin levels, and gastric acid secretion.
Main Methods:
- Comparison of serum gastrin levels between obese (ob/ob) and lean mice at different ages.
- Assessment of antral gastrin concentration and maximal gastric acid output.
- Analysis of gastrointestinal size and proliferative status.
Main Results:
- Obese mice showed significantly elevated serum gastrin levels compared to lean controls, particularly at 5 and 10 weeks of age.
- Hypergastrinemia persisted even when food intake was controlled.
- Maximal gastric acid output was reduced in obese mice.
Conclusions:
- The hypergastrinemia observed in obese mice is not a result of hyperphagia.
- Reduced acid inhibition of gastrin release is a likely cause of elevated gastrin levels in obese mice.
