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Related Experiment Videos

Intestinal spirochetosis of the vermiform appendix.

R Henrik-Nielsen, F A Lundbeck, P S Teglbjaerg

    Gastroenterology
    |April 1, 1985
    PubMed
    Summary

    Spirochetes were found in 12.3% of appendices with pseudoappendicitis and 0.7% with acute appendicitis. This suggests a potential link between spirochetes and appendiceal conditions, warranting further investigation.

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    Area of Science:

    • Microbiology
    • Gastroenterology
    • Pathology

    Background:

    • Spirochetes are spiral-shaped bacteria that can cause various infections.
    • Appendicitis is a common surgical emergency.
    • The role of spirochetes in appendiceal pathology is not well understood.

    Purpose of the Study:

    • To investigate the prevalence of spirochetes in surgically removed appendices.
    • To determine if spirochetes are associated with acute appendicitis or other appendiceal conditions.
    • To characterize the morphology of appendiceal spirochetes.

    Main Methods:

    • Histological examination of 681 surgically removed appendices.
    • Microscopic detection of spirochetes.
    • Ultrastructural analysis of spirochetes using negative staining and ultrathin sectioning.

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    Main Results:

    • Spirochetes were detected in 12.3% of appendices with pseudoappendicitis (histologically normal but clinically suspected appendicitis).
    • Spirochetes were found in only 0.7% of appendices with confirmed acute appendicitis (p < 0.05).
    • Two cases (1.9%) of appendiceal spirochetosis were identified in appendices removed for other reasons (p < 0.05).
    • The ultrastructure of the identified spirochetes was similar to Brachyspira aalborgi.

    Conclusions:

    • Spirochetes may play a role in pseudoappendicitis.
    • The association between spirochetes and acute appendicitis appears weak.
    • Appendiceal spirochetosis is a distinct entity that may require further study.