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Related Concept Videos

Evolutionary Relationships through Genome Comparisons02:54

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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Related Experiment Video

Updated: Jun 4, 2025

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues
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WebSEQ: A New Tool for Democratizing Omics Data Sharing.

Shane A Liddelow1, Ye Zhang2, Steven A Sloan3

  • 1Neuroscience Institute, NYU Grossman School of Medicine, New York City, New York, USA.

Glia
|December 26, 2024
PubMed
Summary

Researchers can now easily share and explore omics data, including transcriptomic, proteomic, and metabolomic datasets, using a new free online tool. This platform requires no coding, making complex molecular data analysis accessible for advancing neuroscience research.

Keywords:
data sharingglialipidomicsomicsproteomicsrnaseq

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Area of Science:

  • Neuroscience
  • Bioinformatics
  • Data Science

Background:

  • Omics datasets (transcriptomic, proteomic, metabolomic) are rapidly generated but difficult to share and analyze.
  • Current public data repositories often lack user-friendly interfaces for data exploration.
  • Researchers face challenges in integrating and interpreting diverse omics data.

Purpose of the Study:

  • To present a free, online, user-friendly platform for sharing analyzed omics data.
  • To enhance the accessibility of molecular data for the scientific community.
  • To facilitate the exploration of transcriptomic, proteomic, and metabolomic data without requiring coding expertise.

Main Methods:

  • Development of a free, web-based tool for omics data sharing.
  • The tool accepts basic data spreadsheets, requiring no prior computational knowledge.
  • Implementation of a searchable and user-friendly interface for data exploration.

Main Results:

  • A functional online platform for sharing basic omics data has been established.
  • The tool enables users to explore transcriptomic, proteomic, and metabolomic datasets.
  • No coding or advanced computational skills are necessary to utilize the platform.

Conclusions:

  • Accessible omics data platforms are crucial for advancing neuroscience research.
  • This tool democratizes the exploration of molecular data, supporting glial diversity and function studies.
  • Simplified data sharing and analysis will accelerate scientific discovery in molecular biology and neuroscience.