Related Experiment Video
Updated: May 8, 2025

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
Published on: December 28, 2017
Severe cutaneous adverse reactions associated with antifungal agents: a pharmacovigilance analysis based on the FDA
Huifang Shan1, Chunyan Wei1, Jingyi Zhang1
1Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, China.
Background:
The aim of this study was to explore the risk of severe cutaneous adverse reactions (SCARs) caused by different antifungal drugs in the real world.
Methods:
We extracted the data from the FDA Adverse Event Reporting System (FAERS) from January 2004 to December 2022 and performed disproportionality analyses to characterize the signal differences of antifungal agents-related SCARs.
Results:
A total of 952 antifungals-related SCARs were identified. Antifungal drugs-related SCARs were more common in the 18-64 age group than other groups, and five agents were detected significant SCAR signals in this age group. Among these antifungals, fluconazole had the strongest associations with the SCARs, and showed significant SCAR signals at all age stages. Six antifungals showed a significant association with SCARs under disproportionality. The reporting odds ratios (RORs) and the 95% confidence intervals (95% CI) for six antifungals were as follows: fluconazole (9.50, 8.62-10.47), caspofungin (8.92, 7.29-10.91), itraconazole (3.48, 2.78-4.35), amphotericin B (2.73, 2.20-3.39), micafungin (2.62, 1.85-3.71) and voriconazole (2.50, 2.12-2.94).
Conclusions:
The data mining of FAERS demonstrated that antifungal drugs were significantly associated with SCARs, which reminded clinicians to continue monitoring patients who are at risk of developing SCARs with the use of these drugs.
Related Concept Videos
Pharmacovigilance
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Allergic Drug Reactions
Local Anesthetics: Adverse Effects
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Hypersensitivities
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

