Related Experiment Video
Updated: May 8, 2025
Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
COVID-19 in pregnancy: Perinatal outcomes and complications
Karolina Akinosoglou1, Georgios Schinas1, Evangelia Papageorgiou2
1Department of Medicine, University of Patras, Patras 26504, Greece.
Insights
Pregnant women with COVID-19 face elevated risks. Delayed emergency department presentation and comorbidities significantly increase hospitalization odds, underscoring the need for timely interventions to improve maternal and perinatal outcomes.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Maternal-Fetal Medicine
Background:
- Pregnant women are at increased risk for severe outcomes from coronavirus disease 2019 (COVID-19).
- Understanding maternal and perinatal outcomes in this population is crucial for clinical management.
Purpose of the Study:
- To investigate the clinical outcomes of pregnant women diagnosed with COVID-19.
- To report on perinatal outcomes and complications associated with maternal COVID-19 infection.
- To review current literature on COVID-19 in pregnancy.
Main Methods:
- Retrospective analysis of 60 pregnant women presenting to a tertiary hospital emergency department (ED) between April 2020 and February 2022.
- Inclusion of maternal and perinatal files, documenting epidemiological data, clinical characteristics, laboratory values, and treatment modalities.
- Exploration of associations between clinical factors and outcomes.
Main Results:
- Twenty-five percent of symptomatic pregnant women required hospitalization; 30% experienced preterm delivery.
- Neonatal intensive care unit (NICU) admission occurred in 10% of neonates, with 5% classified as small for gestational age.
- Delayed ED presentation (adj. OR 2.3) and comorbidities (adj. OR 16.13) independently predicted hospitalization; adverse fetal outcomes were not significantly linked to hospitalization.
Conclusions:
- Delayed emergency department presentation and pre-existing comorbidities are significant predictors of hospitalization in pregnant COVID-19 patients.
- Effective management requires continuous, specific guidance and timely interventions to reduce maternal and perinatal morbidity and mortality.
Background:
The risk of severe coronavirus disease 2019 (COVID-19) in pregnant women is elevated.
Aim:
To examine the outcomes of pregnant women with COVID-19 and report perinatal outcomes and complications, while providing a brief review of current literature.
Methods:
The study included pregnant women presenting from April 2020 to February 2022 to the emergency department (ED) of a tertiary hospital. We retrospectively recorded the maternal and perinatal files, including patient epidemiological and clinical characteristics, laboratory values, outcomes, treatment modalities and associations were explored.
Results:
Among the 60 pregnant women, 25% required hospitalization, all of whom were symptomatic. Preterm delivery occurred in 30% of cases. Ten percent of neonates required admission to the neonatal intensive care unit, and 5% were classified as small for their gestational age. All mothers survived COVID-19 and pregnancy, with 6.6% requiring invasive mechanical ventilation. Preterm delivery rates did not differ between hospitalized and non-hospitalized pregnant women; composite unfavorable perinatal outcomes, including stillbirth, small for gestational age, or neonatal intensive care unit (ICU) admission, did not significantly increase in the cases hospitalized for COVID-19 (P = 0.09). The odds of hospitalization increased 2.3-fold for each day of delayed ED presentation [adj. OR (95%CI: 1.46-3.624), P < 0.001]. Comorbidity status was an independent predictor of hospitalization, albeit with marginal significance [adj. OR = 16.13 (95%CI: 1.021-255.146), P = 0.048]. No independent predictors of adverse fetal outcome (composite) were identified, and eventual hospitalization failed to reach statistical significance by a slight margin (P = 0.054).
Conclusion:
Delayed ED presentation and comorbidities increase hospitalization odds. This study highlights the importance of continuous and specific guidance for managing pregnant COVID-19 patients, including timely and appropriate interventions to minimize maternal and perinatal morbidity and mortality.
More Related Videos
08:50A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
05:31Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
Related Concept Videos
01:07Teratogenicity
01:30Pneumonia III: Complications and Assessment
01:22Diabetes Mellitus: Type 2 and Gestational
01:23Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
01:26Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
01:29Pneumonia II: Pathophysiology