Hemorrhagic stroke and atherogenic markers - is there any relation?

Area of Science:

• Cardiology
• Neurology
• Clinical Biochemistry

Background:

• The triglyceride/high-density lipoprotein (TG/HDL) ratio is a recognized cardiovascular risk marker.
• The association between serum lipid levels and hemorrhagic stroke (HS) outcomes is not well-established.
• Investigating novel lipid indices for HS patient mortality prediction is crucial.

Purpose of the Study:

• To explore the association between the TG/HDL index and in-hospital mortality in patients diagnosed with HS.
• To determine if the TG/HDL index can serve as an independent predictor of mortality in HS patients.
• To evaluate the clinical utility of the TG/HDL index in cardiovascular risk assessment for HS.

Main Methods:

• A retrospective-prospective study design was employed.
• Data from 104 hospitalized HS patients were analyzed between January 2020 and August 2023.
• Univariable and multivariable logistic regression analyses were performed to identify independent predictors of mortality.

Main Results:

• The TG/HDL index was identified as an independent predictor of in-hospital mortality (OR, 0.368; 95% CI, 0.173-0.863; P = 0.020).
• Other independent predictors included age, atrial fibrillation, and glucose level.
• A lower TG/HDL index was associated with decreased mortality risk.

Conclusions:

• The TG/HDL index is a valuable tool for assessing cardiovascular risk in HS patients.
• Findings support the integration of the TG/HDL index into comprehensive risk assessment and management strategies for HS.
• Further research is warranted to validate these findings and explore therapeutic implications.