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Cell therapy in kidney diseases: advancing treatments for renal regeneration

Amankeldi A Salybekov1, Aiman Kinzhebay1, Shuzo Kobayashi2

  • 1Qazaq Institute of Innovative Medicine, Regenerative Medicine Division, Cell and Gene Therapy Department, Astana, Kazakhstan.

Frontiers in Cell and Developmental Biology
|December 26, 2024
PubMed

Insights

Cell therapies show promise for kidney diseases like acute kidney injury (AKI) and chronic kidney disease (CKD). Research is advancing to overcome challenges in cell sourcing, delivery, and long-term outcomes for improved patient treatment.

Area of Science:

  • Nephrology
  • Regenerative Medicine
  • Cell Therapy

Background:

  • Kidney diseases (AKI, CKD) are a major global health issue.
  • Diabetes and hypertension increase kidney disease risk.
  • Current treatments for kidney disease are limited.

Purpose of the Study:

  • To review the current state of cell therapies for kidney diseases.
  • To explore preclinical and clinical advancements in cell-based kidney treatments.
  • To identify challenges and future directions in kidney disease cell therapy.

Main Methods:

  • Comprehensive literature review of cell therapy research in kidney disease.
  • Analysis of preclinical studies and clinical trial data.
  • Evaluation of mechanisms of action for cell-based interventions.

Main Results:

  • Cell therapies demonstrate kidney protection via paracrine signaling, immune modulation, and tissue integration.
  • Positive outcomes observed in both acute kidney injury (AKI) and chronic kidney disease (CKD) models.
  • Cellular interventions offer potential for novel kidney disease management.

Conclusions:

  • Cell therapy is a promising avenue for treating kidney diseases.
  • Further research is needed to optimize cell sourcing, delivery, and long-term efficacy.
  • Enhancing cell function and refining delivery techniques are key to improving clinical outcomes.
Keywords:
CD34 cellsacute kidney injurycell therapychronic kidney diseaseskidney diseasesmesenchimal stem cells

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