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A Novel Method: Super-selective Adrenal Venous Sampling
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Beyond The Basics: Unveiling Superior Vena Cava Compression in Hodgkin's Lymphoma
Shivendra Tangutoori1, Dedeepya Gullapalli1, Sai S Kommineni1
1Internal Medicine, Appalachian Regional Healthcare, Harlan, USA.
Cureus
|December 26, 2024
Summary
This case report details a rare presentation of advanced Hodgkin lymphoma (HL) with severe eosinophilia and superior vena cava syndrome. Effective chemotherapy led to significant symptom relief and tumor reduction.
Area of Science:
- Oncology
- Hematology
- Internal Medicine
Background:
- Hodgkin lymphoma (HL) is a lymphoid malignancy typically presenting with systemic symptoms.
- Mediastinal involvement is common, but superior vena cava (SVC) syndrome is rare.
- Eosinophilia occurs in about 15% of HL cases.
Observation:
- A 52-year-old male with chronic pruritus, kidney disease, and hepatitis B presented with cough, dyspnea, Horner's syndrome, and SVC syndrome.
- Imaging showed a mediastinal mass and pleural effusion.
- Biopsy confirmed classical HL with severe eosinophilia and a pruritic rash.
Findings:
- The patient was diagnosed with stage IV B (bulky) HL.
- Treatment with brentuximab vedotin plus AVD resulted in significant symptom resolution.
- Tumor size was markedly reduced following chemotherapy.
Implications:
- This case highlights HL as a differential diagnosis in patients with chronic pruritus, eosinophilia, and mediastinal masses.
- Comprehensive evaluation is crucial for complex HL presentations.
- Modern chemotherapy regimens demonstrate efficacy in advanced HL.
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