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Area of Science:

  • Clinical Chemistry
  • Urology
  • Biomedical Diagnostics

Background:

  • Growing interest in capillary blood sampling (CBS) for biochemical analyte testing.
  • CBS offers advantages for home surveillance of chronic conditions.
  • Prostate cancer screening and monitoring often rely on total prostate-specific antigen (TPSA) levels.

Purpose of the Study:

  • To evaluate the viability and feasibility of using CBS for TPSA testing.
  • To compare TPSA concentrations measured from capillary and venous blood samples.
  • To assess the stability of TPSA in capillary blood samples.

Main Methods:

  • Recruitment of men with known prostate disease from a urology clinic.
  • Collection of capillary blood samples via finger-prick and simultaneous venous blood samples.
  • Measurement of TPSA using validated immunoassays on Roche and Beckman platforms.

Main Results:

  • High correlation (r = 0.997) between TPSA levels from CBS and venous samples across a wide concentration range.
  • Negligible average bias (1.07%) and no significant proportional or constant bias.
  • TPSA demonstrated stability in CBS stored at ambient temperature for up to 8 days.

Conclusions:

  • Capillary blood sampling is a highly correlated and feasible method for TPSA measurement compared to venous sampling.
  • Negligible bias suggests CBS can be a reliable alternative for TPSA testing.
  • Further validation is needed for TPSA measurement in CBS and its clinical utility in prostate disease management.