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Does elevated serum progesterone on the day of human chorionic gonadotropin administration decrease live birth rates?

K C Humm^1,2,3, Y Ibrahim^1,3, L E Dodge^1,3

¹Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, 330 Brookline Ave., KS 3, Boston, MA 02215, USA

Journal of Reproductive Health and Medicine

|December 26, 2024

Summary

This summary is machine-generated.

Elevated serum progesterone on the day of human chorionic gonadotropin (HCG) administration is linked to decreased pregnancy and live birth rates in in vitro fertilization (IVF) cycles. This trend persists even after accounting for other factors.

Keywords:

Progesterone Premature luteinization In vitro fertilization Live birth rates

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Area of Science:

Reproductive Endocrinology
In Vitro Fertilization (IVF)

Background:

The effect of elevated serum progesterone on in vitro fertilization (IVF) outcomes is not fully understood.
Progesterone plays a crucial role in preparing the endometrium for implantation.

Purpose of the Study:

To investigate the association between elevated serum progesterone levels on the day of human chorionic gonadotropin (HCG) administration and pregnancy/live birth rates in IVF.
To synthesize current literature and present data on this topic.

Main Methods:

Mini-review of existing literature.
Inclusion of original data from the authors' institution.
Analysis of serum progesterone levels on HCG administration day.

Main Results:

A trend of decreasing pregnancy and live birth rates with increasing serum progesterone levels on the day of HCG administration was observed.
This association remained significant even after adjusting for potential confounding factors.

Conclusions:

Elevated serum progesterone on the day of HCG administration appears to negatively impact IVF success rates.
The majority of studies investigating this phenomenon report consistent findings, suggesting a detrimental effect.