Role of the Forkhead box family protein FOXF2 in the progression of solid tumor: systematic review

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Yuzhen Zheng1,2, Liusheng Wu3, Zhenyu Hu1,2

  • 1Department of Thoracic Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510655, China.

Journal of Cancer Research and Clinical Oncology
|December 26, 2024
PubMed
Abstract

Insights

The FOXF2 gene plays a crucial role in various biological processes and cancer development. Understanding its function offers potential for new cancer therapies.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • FOXF2 is implicated in central nervous system development, tissue homeostasis, and embryonic organogenesis.
  • It influences key cellular processes such as epithelia-mesenchymal interactions.

Purpose of the Study:

  • To elucidate the role of FOXF2 in cancer growth and development.
  • To identify potential therapeutic targets for novel cancer treatment strategies.

Main Methods:

  • This review synthesizes existing research on FOXF2's impact on tumor cells.
  • It analyzes molecular mechanisms of FOXF2 across various cancer types and embryonic development.

Main Results:

  • FOXF2 affects cellular phenotype transformation, migration, invasion, and proliferation.
  • It influences circulating tumor cell colonization and metastatic nodule formation.
  • FOXF2's roles in hepatocellular, esophageal, breast, colon, lung, and prostate cancers are examined.

Conclusions:

  • FOXF2, a Forkhead Box gene, encodes a transcription factor crucial for gene activation.
  • This review details FOXF2's multifaceted functions in cancer progression and embryonic development.
Keywords:
CancerCancer developmentCancer progressionFOX2Signal pathway

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