Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

30
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
30
Nephrons01:10

Nephrons

1.5K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
1.5K
Dialysis01:27

Dialysis

226
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
226
Renal Corpuscle01:20

Renal Corpuscle

1.1K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
1.1K
Kidney Structure01:45

Kidney Structure

66.8K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
66.8K
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

34
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
34

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pivotal Clinical Trials in C3 Glomerulopathy: answers and remaining uncertainties.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same author

Extracellular vesicles exposing complement split products are associated with kidney involvement in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).

RMD open·2026
Same author

Correction: Somatic morbidity in bipolar disorders.

International journal of bipolar disorders·2026
Same author

An exploration of markers of microvascular dysfunction in kidney transplant recipients randomized to belatacept: no clinical impact of CNIs on endothelial function.

Frontiers in transplantation·2026
Same author

Long-Term Opioid Therapy Tapering and Risk of Substance Use Disorder and Overdose: Differences by Opioid Dose and Duration.

Journal of general internal medicine·2026
Same author

Large-scale proteome profiling identifies circulating biomarkers for disease activity and organ involvement in ANCA-associated vasculitides.

Frontiers in immunology·2026
Same journal

Notice of Retraction. Ren Y, et al. Personality Traits and Social Isolation in Older Adults. JAMA Netw Open. 2026;9(5):e269569.

JAMA network open·2026
Same journal

Error in Grant Number in Funding/Support Section.

JAMA network open·2026
Same journal

The Supplementary Role of Friends in Caregiving Networks.

JAMA network open·2026
Same journal

Urbanicity, Neighborhood Conditions, and Dementia Mortality.

JAMA network open·2026
Same journal

Equity and Cancer Survival Among Veterans Health Administration Patients: A Systematic Review and Meta-Analysis.

JAMA network open·2026
Same journal

Limbic System Microstructure in Neonates With Antenatal Opioid Exposure.

JAMA network open·2026
See all related articles

Related Experiment Video

Updated: May 8, 2025

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

369

Kidney Function Decline After COVID-19 Infection.

Viyaasan Mahalingasivam1,2,3, Anne-Laure Faucon2,4, Arvid Sjölander2

  • 1Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.

JAMA Network Open
|December 26, 2024
PubMed
Summary
This summary is machine-generated.

COVID-19 accelerates kidney function decline more than pneumonia, especially after hospitalization. Close monitoring of kidney function in hospitalized COVID-19 patients is crucial for managing chronic kidney disease.

More Related Videos

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney
08:53

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

Published on: August 9, 2014

43.9K
Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
10:25

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Published on: November 10, 2021

1.7K

Related Experiment Videos

Last Updated: May 8, 2025

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

369
Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney
08:53

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

Published on: August 9, 2014

43.9K
Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
10:25

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Published on: November 10, 2021

1.7K

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Public Health

Background:

  • COVID-19 is linked to acute kidney injury, but long-term kidney function effects remain unclear.
  • Understanding post-infection kidney function trajectories is vital for patient outcomes.

Purpose of the Study:

  • To compare kidney function decline after COVID-19 versus other respiratory infections.
  • To assess the impact of COVID-19 on estimated glomerular filtration rate (eGFR) over time.

Main Methods:

  • A cohort study utilizing Stockholm Creatinine Measurements (SCREAM) Project data (2018-2022).
  • Included hospitalized and non-hospitalized adults with pre-infection eGFR measurements.
  • Compared annual eGFR change using linear regression models for COVID-19 and pneumonia cohorts.

Main Results:

  • COVID-19 cohort: 134,565 individuals; Pneumonia cohort: 35,987 individuals.
  • Both groups showed accelerated annual eGFR decline.
  • COVID-19 led to a 3.4% decline vs. 2.3% for pneumonia; hospitalization intensified decline in COVID-19 patients (5.4%).

Conclusions:

  • COVID-19 is associated with accelerated kidney function decline, more so than pneumonia, particularly post-hospitalization.
  • Hospitalized COVID-19 patients require vigilant kidney function monitoring for early chronic kidney disease management.