Related Experiment Video
Updated: Jun 4, 2025
Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation
Published on: June 7, 2016
Local and network changes after multichannel transcranial direct current stimulation using magnetoencephalography in
Maeva Daoud1, Samuel Medina Villalon2, Ricardo Salvador3
1Aix-Marseille Université, INSERM, INS, Institut de Neurosciences des Systèmes, Marseille 13005, France.
Objective:
Non-invasive neuromodulation techniques, particularly transcranial direct current stimulation (tDCS), are promising for drug-resistant epilepsy (DRE), though the mechanisms of their efficacy remain unclear. This study aims to (i) investigate tDCS neurophysiological mechanisms using a personalized multichannel protocol with magnetoencephalography (MEG) and (ii) assess post-tDCS changes in brain connectivity, correlating them with clinical outcomes.
Methods:
Seventeen patients with focal DRE underwent three cycles of tDCS over five days, each consisting of 40-minute stimulations targeting the epileptogenic zone (EZ) identified via stereo-EEG. MEG was performed before and after sessions to assess functional connectivity (FC) and power spectral density (PSD),estimated at source level (beamforming).
Results:
Five of fourteen patients experienced a seizure frequency reduction > 50 %. Distinct PSD changes were seen across frequency bands, with reduced FC in responders and increased connectivity in non-responders (p < 0.05). No significant differences were observed between EZ network and non-involved networks. Responders also had higher baseline FC, suggesting it could predict clinical response to tDCS in DRE.
Conclusions:
Personalized multichannel tDCS induces neurophysiological changes associated with seizure reduction in DRE.
Significance:
These results provide valuable insights into tDCS effects on epileptic brain networks, informing future clinical applications in epilepsy treatment.
