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Tertiary lymphoid structures in nasopharyngeal carcinoma: A multi-institutional study
Alhadi Almangush1, Miia Ruuskanen2, Jaana Hagström3
1Department of Pathology, University of Helsinki, P.O. Box 21, Helsinki FI-00014, Finland; Institute of Biomedicine, Pathology, University of Turku, Turku, Finland; Research Program in Systems Oncology, University of Helsinki, Helsinki, Finland; Faculty of Dentistry, Misurata University, Misurata, Libya.
Tertiary lymphoid structures (TLSs) presence in nasopharyngeal carcinoma (NPC) tumors correlates with improved patient survival. Absence of TLSs is linked to poorer disease-specific and overall survival, suggesting prognostic value.
Area of Science:
- Oncology
- Immunology
- Pathology
Background:
- Tertiary lymphoid structures (TLSs) are implicated in the prognosis of various cancers.
- The clinical relevance of TLSs in nasopharyngeal carcinoma (NPC) remains unclear.
Purpose of the Study:
- To investigate the prognostic significance of TLSs in nasopharyngeal carcinoma (NPC).
Main Methods:
- A population-based, multicenter study included 115 NPC patients from five Finnish university hospitals.
- TLSs were evaluated using routine hematoxylin and eosin (HE)-stained tissue sections.
Main Results:
- The presence of TLSs was significantly associated with improved survival in NPC patients.
- Absence of TLSs correlated with poorer disease-specific survival (HR 1.96) and overall survival (HR 1.68).
Conclusions:
- TLSs appear to be a significant prognostic factor in NPC.
- TLS assessment may assist in understanding NPC's clinical behavior and guiding treatment strategies.
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