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A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
Published on: July 28, 2020
DERMATOFIBROSARCOMA PROTUBERANS: WIDE LOCAL EXCISION AS DERMATOSURGICAL APPROACH WITH FAVOURABLE FINAL OUTCOME-CASE
G Tchernev1, V Broshtilova2, S Kordeva3
11Onkoderma - Clinic for Dermatology, Venereology and Dermatologic Surgery, Sofia; 2Department of Dermatology and Venereology, Medical Institute of Ministry of Interior, Sofia, Bulgaria.
Abstract:
Dermatofibrosarcoma protuberans (DFSP) is a rare, low-grade cutaneous sarcoma typically found on the proximal extremities and the trunk, characterized by infiltrative growth and low risk of metastasis. High rates of local recurrence or relatively large tumor sizes can significantly complicate therapeutic management, particularly when 1) surgical intervention is not adequately performed and /or 2 access to newer medications is limited or their high cost imposes a financial burden on patients. We present the case of a 63-year-old male with a histologically confirmed dermatofibrosarcoma protuberans, measuring 6 cm in diameter, located on the right dorsal region, accompanied by several confluent multifocal nodules situated infralaterally to the primary formation. Wide surgical excision with 5 mm margins in all directions was performed, achieving clean resection margins in all directions and short term recidive-free outcome. This report also provides a brief overview of the therapeutic options available for DFSP, emphasizing the surgical approach, which remains the gold standard for treatment.
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