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Long-term effects of Q-switched ruby laser on monkey anterior chamber angle
Investigative Ophthalmology & Visual Science
|February 1, 1985
Summary
Pulsed laser treatment of the trabecular meshwork in monkeys did not create permanent fistulas. Microscopic analysis revealed localized lesions but no persistent penetration to Schlemm
Area of Science:
- Ophthalmology
- Laser Surgery
- Glaucoma Research
Background:
- Pulsed lasers are explored for glaucoma treatment.
- The risk of permanent fistulas from laser trabecular treatment is not fully understood.
Purpose of the Study:
- To investigate if pulsed lasers can cause permanent fistulas.
- To assess the safety and efficacy of Q-switched ruby laser pulses on the trabecular meshwork.
Main Methods:
- Q-switched ruby laser pulses applied to the trabecular meshwork of rhesus monkey eyes.
- Clinical examinations, intraocular pressure (IOP) measurements, and perfusion tests conducted over 2 months.
- Light microscopy and scanning electron microscopy used for detailed tissue analysis.
Main Results:
- No permanent fistulas or adverse effects on ocular structures observed.
- Transient mild inflammation occurred in some eyes.
- Microscopy showed localized trabecular lesions without penetration to Schlemm's canal; healing obliterated some meshwork and canal areas.
Conclusions:
- Q-switched ruby laser pulses do not appear to create permanent fistulas.
- The observed trabecular meshwork changes are similar to those from argon laser treatment.
- Any IOP effects are unlikely due to trabeculopuncture or fistula formation.