Related Experiment Video

Updated: Jun 4, 2025

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

5.3K

Remimazolam alleviates sleep deprivation induced anxiety-like behaviors via regulating the STING pathway

Jun Fan1, Jumian Feng1, Lin Yang1

  • 1Department of Anesthesiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, China.

Neuroscience Letters
|December 26, 2024
PubMed

Insights

Remimazolam effectively reduces anxiety caused by chronic sleep deprivation (CSD) by preserving neuronal activity and blocking the STING pathway. This offers a new therapeutic approach for sleep deprivation-induced anxiety disorders.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Sleep Medicine

Background:

  • Sleep loss is a prevalent issue linked to increased anxiety disorders.
  • Benzodiazepines are common anxiolytics, with remimazolam showing promise for preoperative anxiety.
  • The impact of remimazolam on chronic sleep deprivation (CSD)-induced anxiety and its mechanisms are not fully understood.

Purpose of the Study:

  • To investigate the efficacy of remimazolam in alleviating anxiety-like behaviors induced by CSD.
  • To explore the molecular mechanisms underlying remimazolam's effects on CSD-induced anxiety.
  • To determine if the STING pathway is involved in CSD-induced anxiety.

Main Methods:

  • Administration of remimazolam to rodents subjected to chronic sleep deprivation.
  • Assessment of anxiety-like behaviors.
  • Measurement of neuronal calcium activity in the hippocampal CA1 region.
  • Analysis of STING pathway activation in the hippocampus.

Main Results:

  • Remimazolam administration significantly alleviated anxiety-like behaviors in CSD rodents.
  • Remimazolam preserved neuronal calcium activity deficits in the hippocampal CA1 region caused by CSD.
  • CSD activated the STING pathway in the hippocampus, an effect blocked by remimazolam.
  • Inhibiting STING activation also reduced CSD-induced anxiety.

Conclusions:

  • Remimazolam is a potential therapeutic agent for anxiety disorders stemming from sleep deprivation.
  • The STING pathway in the hippocampus plays a crucial role in CSD-induced anxiety.
  • This study provides novel insights into the neurobiological basis of sleep deprivation-related anxiety.
Keywords:
AnxietyCA1RemimazolamSTING

More Related Videos

Polygraphic Recording Procedure for Measuring Sleep in Mice08:45

Polygraphic Recording Procedure for Measuring Sleep in Mice

Published on: January 25, 2016

23.5K
Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements05:42

Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements

Published on: January 7, 2019

31.2K

Related Concept Videos

Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

Sedatives and Hypnotics Drugs: Miscellaneous Agents

Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
145
Sedatives and Hypnotics: Overview01:23

Sedatives and Hypnotics: Overview

Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
274
Management of Insomnia01:19

Management of Insomnia

The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
230
CNS Depressants: Barbiturates and Benzodiazepines01:14

CNS Depressants: Barbiturates and Benzodiazepines

CNS depressants include drugs from the category of barbiturates and benzodiazepines. They are valuable medications for managing anxiety disorders and insomnia. Barbiturates, once used to induce and maintain sleep, have been replaced mainly by benzodiazepines due to barbiturate's toxicity, tolerance, and overdose risks. They interact with GABAA receptors, leading to sedation at low doses and potentially coma and death at higher doses. Phenobarbital, a long-acting barbiturate, possesses...
222
Anxiolytic Drugs: Benzodiazepines and Buspirone01:29

Anxiolytic Drugs: Benzodiazepines and Buspirone

Benzodiazepines are a class of anxiolytic drugs known for their rapid efficacy and high therapeutic-to-lethal dose ratio, but with a potential risk of drug dependence. These drugs are lipophilic, allowing for rapid absorption after oral administration, eventually reaching the central nervous system (CNS). Once in the CNS, benzodiazepines bind to the allosteric site of the GABAA receptor. This binding enhances the inhibitory effects of the neurotransmitter GABA. By doing so, they prevent...
507
Sedatives and Hypnotics Drugs: Benzodiazepines01:19

Sedatives and Hypnotics Drugs: Benzodiazepines

Benzodiazepines have both sedative and hypnotic properties. They include compounds such as diazepam (Valium) and alprazolam (Xanax). Structurally, their cores are similar, consisting of the fusion of a benzene ring and a diazepine ring, but they share a common mechanism of action in the central nervous system (CNS).
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
186